Gadolinium and nephrogenic systemic fibrosis

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Gadolinium-associated nephrogenic systemic fibrosis.

Nephrogenic systemic fibrosis is a progressive, potentially fatal multiorgan system fibrosing disease related to exposure of patients with renal failure to the gadolinium-based contrast agents used in magnetic resonance imaging. Because of this relationship between nephrogenic systemic fibrosis and gadolinium-based contrast agents, the U.S. Food and Drug Administration currently warns against u...

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Correspondence to: Dr Kei Pin Lin Tel: (65) 6222 3322 Fax: (65) 6326 5242 Email: binglin8@ yahoo.com.sg Nephrogenic systemic fibrosis (NSF) is a rare multisystem disease characterised by widespread tissue fibrosis. It is recognised for its epidemiological association in patients with chronic renal failure, after administration of gadolinium-chelate magnetic resonance (MR) contrast agent, partic...

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Nephrogenic systemic fibrosis following gadolinium administration.

To the Editor: Nephrogenic systemic fibrosis (NSF) is an emerging medical entity in patients with renal disease, which results in progressive cutaneous and systemic fibrosis. It is a rare disorder that has been recognized in patients with renal impairment since 2000.1 Patients with NSF demonstrate symmetric dermal and subcutaneous fibrosis evidenced by increasing skin induration on clinical exa...

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No Association between Gadolinium-Based Contrast Agents and Development of Nephrogenic Systemic Fibrosis: a Case Study

Nephrogenic systemic fibrosis (NSF), previously known as nephrogenic fibrosing dermopathy, is an emerging systemic fibrosing disorder that develops in the setting of renal insufficiency. Nephrogenic fibrosing dermopathy (NFD) is a fibrosing condition of the skin which shows an increased number of dendritic cells, fibroblasts and thickened collagen fibers resembling scleromyxedema. It is charact...

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WARNING: NEPHROGENIC SYSTEMIC FIBROSIS Gadolinium-based contrast agents increase the risk for nephrogenic systemic fibrosis

In these patients, avoid use of gadolinium-based contrast agents unless the diagnostic information is essential and not available with non-contrast enhanced magnetic resonance imaging (MRI). NSF may result in fatal or debilitating systemic fibrosis affecting the skin, muscle and internal organs. Screen all patients for renal dysfunction by obtaining a history and/or laboratory tests. When admin...

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ژورنال

عنوان ژورنال: Kidney International

سال: 2007

ISSN: 0085-2538

DOI: 10.1038/sj.ki.5002338